Introduction to PHIP

Existing para-hydrogen induced polarization (PHIP) instrumentation relies on four factors to hyperpolarize endogenous substances: a static magnetic field (Bo), temperature, pressure, and software sample control. These hyperpolarized sub- stances have enhanced magnetic resonance imaging (MRI) signals over 1000 fold, allowing for molecular imaging. We discuss the improvements in B o generation, sample heating, sample manipulation, and software sample control to produce polarized HEP. We show that HEP polarization doubles from previous efforts by use of: 1) A voltage controlled voltage source, 2) A modified pinch valve, and 3) LabView software sample control developed in our laboratory  more detail

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